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4.1.1 Evidence of mtDAMPs release Multiple studies have measured cell-free mitochondrial DNA (cf-mtDNA) in cardiac surgery patients

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Results revealed that administering albumin infusion at threshold of 5 L of ascites removal led to a significant reduction in serum creatinine levels by 0.05 (95%CI: 0.01-0.097) and 0.048 (0.01-0.086) mg/dl/day, and an increase in serum sodium levels of 0.34 (95%CI: 0.12-0.6) and 0.39 (0.16-0.61) mEq/L/day, respectively, compared to those who did not receive albumin infusion (Figure).The RD plots also indicated elevated serum creatine and reduced serum sodium levels after draining 3-4 liters of fluid, approaching levels similar to or worse than with albumin infusion at 5 liters or more, suggesting potential benefits for albumin replacement at a lower cut-off